General Hospital Spoilers: September 22 – October 3, 2025

Monica’s Farewell, Shocking Returns, and Explosive Family Secrets

The next two weeks in General Hospital are poised to shake Port Charles to its core. From a heartbreaking farewell to Monica, to a jaw-dropping mystery patient who looks exactly like Nathan, to family betrayals that threaten to destroy bonds forever—every storyline is set to escalate. Here’s a full breakdown of what viewers can expect between September 22 and October 3, 2025.

Carly and Sonny Reflect on Monica’s Legacy

News of Monica’s departure weighs heavily on the Quartermaine family and ripples outward across Port Charles. Despite a history filled with grudges and misunderstandings, Carly and Sonny find themselves deeply affected by Monica’s absence.

The two reminisce about her many contributions, not only as a doctor and matriarch but as someone who, despite her stern exterior, always carried compassion at her core. Both share warm memories and begin brainstorming ways to help Jason and Michael navigate this painful transition. For Jason, losing Monica is not just about family—it’s the closing of a chapter with the woman who was often the grounding force in his life.

Anna’s Shocking Discovery: Is Nathan Alive?

Meanwhile, Anna Devane faces one of the most startling developments in years. A new patient surfaces who looks exactly like Nathan West. The resemblance is uncanny, leaving Anna stunned. If Nathan truly is back from the dead, the only explanation points to Faison’s twisted legacy.

Though Faison himself is gone, his sinister medical projects appear to live on. Could this be another experiment brought to life by his followers? Dante is handed the task of uncovering the truth, but as Anna reels from the shock, she is also blindsided with new evidence—a baseball bat found at Drew’s house, bearing Kai’s fingerprints.

Kai Under Fire at the PCPD

This discovery immediately puts Kai on the police radar. He is dragged in for questioning at the Port Charles Police Department, with investigators eager to know his connection to the weapon. Kai scrambles to protect himself and, more importantly, Trina, knowing that one wrong move could drag them both into a legal nightmare.

Still, he remains firmly on the suspect list, and it’s clear this investigation is far from over.

Molly’s Confession and Alexis’s Advice

Across town, Molly finally opens up to her mother Alexis about a secret she has been carrying: her growing feelings for Cody. Alexis, never one to mince words, admits she has little faith in Cody’s character, but she refrains from dictating her daughter’s choices. Instead, she advises Molly to take a rare risk and “follow her heart.”

It’s advice Molly never expected to hear from her cautious mother, but it may be the push she needs to face her true emotions.

Brit and Rocco’s Emotional Reunion

Elsewhere, Brit seizes a heartfelt opportunity to reconnect with Rocco. Their emotional conversation highlights the unique bond between them, despite not being biologically related.

Rocco reassures Brit that he sees her as a mother figure, and Brit, in turn, expresses her gratitude for his understanding of her past mistakes. Their surrogate family connection is reaffirmed, bringing both comfort and closure.

Trina’s Heartbreak: Porsche’s Betrayal

Determined to help Kai avoid further police scrutiny, Trina seeks her mother’s guidance. However, in an emotional twist, Trina stumbles upon a devastating scene: Porsche and Isaiah caught in an intimate moment.

The betrayal leaves Trina heartbroken and conflicted, shaking her trust in her mother and deepening her turmoil. How will Porsche explain her actions to her daughter—and will Trina ever be able to forgive her?

Monica’s Funeral Brings Chaos

As Port Charles gathers to say a final goodbye, Monica’s funeral becomes a moment of collective grief. Relatives, friends, and colleagues come together to honor her memory. But what should have been a solemn farewell quickly erupts into chaos.

Midway through the service, Monica’s younger sister suddenly appears—an arrival that shocks the Quartermaine family and reignites old tensions.

Tracy and Monica’s Lost Sister Face Off

During the week of September 29 – October 3, a dramatic confrontation unfolds. Tracy and Monica’s long-lost sister clash in a heated argument, reigniting family feuds that had been buried for decades.

Adding to the intrigue, fans will see Erika Slezak step into the role of Monica’s sister, bringing a fresh layer of depth and intensity to the already turbulent Quartermaine saga.

Willow Manipulates Chase

In another brewing storm, Willow pushes hard to convince Chase that Michael is the one responsible for Drew’s shooting. Willow’s subtle but relentless manipulation plants dangerous doubts in Chase’s mind. If Chase takes the bait, Michael’s entire world could be upended.

Joss and Vaughn’s Unexpected Guest

Finally, Joss and Vaughn are caught off guard when they receive a surprise visit from someone out of their past. Speculation swirls that this visitor is none other than Nathan, returning from the dead in a shocking twist.

And what about Dex? His fate still hangs in the balance, leaving viewers to wonder: does he have a chance to survive and return to the fold?

Final Thoughts

From Monica’s emotional farewell to shocking resurrections and explosive betrayals, these two weeks promise to deliver everything fans crave from General Hospital: heartbreak, suspense, romance, and scandal. With long-lost family members emerging, manipulative plots unfolding, and the possibility of the dead returning to the living, the fabric of Port Charles will never be the same.

General Hospital Spoilers: Shocking Returns, Family Betrayals, and Monica’s Emotional Farewell

The next two weeks in General Hospital promise a whirlwind of heartbreak, mystery, and unexpected reunions as Port Charles braces for life-changing twists. From Monica’s devastating departure to a possible resurrection and family betrayals, the stage is set for high drama that will ripple across every corner of the community.

Carly and Sonny Revisit the Quartermaine Legacy

After receiving the heartbreaking news of Monica’s passing, Carly and Sonny take time to reflect on the woman who was, in many ways, the glue holding the Quartermaine family together. Despite years of grudges and old conflicts, both admit they have fond memories of Monica. Her quiet strength and her enduring loyalty left an impression that even time and rivalry could not erase.

The couple shares concern over how Jason and Michael will cope with the loss. While Jason has always carried an emotional bond with Monica that runs deep, Michael has also relied on her for wisdom. Carly and Sonny’s conversations turn toward how best to support them—proof that Monica’s legacy transcends past animosities.

Anna Faces a Haunting Discovery

Meanwhile, Anna Devane finds herself rocked to the core. A new patient appears who looks exactly like Nathan West. Anna is left to question the impossible: could Nathan truly be alive? If so, the shadow of Faison looms large once again. Though long gone, Faison’s sinister dynasty and twisted medical projects may still be alive, continuing to wreak havoc from the grave.

Dante is quickly tasked with investigating the mysterious patient’s identity, but Anna is pulled into another shocking revelation. A baseball bat bearing Kai’s fingerprints has been found at Drew’s house. The evidence places Kai under suspicion in a dangerous new investigation.

Kai Under Fire – And Trina Torn

With Kai brought into the PCPD for questioning, the stakes rise for both him and Trina. Though he may try to talk his way out of trouble, the discovery cannot be easily explained. Trina, determined to shield him from police scrutiny, seeks out her mother for help.

But in doing so, Trina stumbles upon a painful truth. She witnesses Portia in an intimate moment with Isaiah, a betrayal that cuts deep. Already carrying the burden of Kai’s troubles, Trina must now wrestle with disappointment in her mother. How Portia explains herself could determine whether their bond survives this latest rupture.

Molly’s Confession to Alexis

In a quieter storyline, Molly turns to Alexis with a confession that could reshape her romantic future: she has feelings for Cody. Alexis, ever the pragmatic mother, cannot bring herself to endorse Cody, whose reputation remains questionable. Yet in a surprising turn, Alexis urges Molly to follow her heart—advice that may lead Molly down a path of both passion and risk.

Brit and Rocco Find Closure

Elsewhere, Brit reconnects with Rocco in a tender exchange filled with forgiveness and honesty. Though not his biological mother, Brit has played a powerful role in his life. The two speak openly about past mistakes, and Brit is touched by Rocco’s willingness to understand. For Rocco, the conversation brings a sense of relief, reaffirming the unique mother-son bond they still share.

Monica’s Funeral – and a Shocking Return

As Port Charles gathers to mourn Monica, her funeral becomes both a celebration of her life and a setting for new drama. Family, friends, and colleagues gather to reminisce about Monica’s memories and say a final goodbye.

But the solemnity of the day is shattered when Monica’s younger sister makes an unexpected entrance. Long thought lost, her return causes chaos in the middle of the service. In the following week, tensions explode as Tracy and this mysterious sibling engage in a heated confrontation.

Fans are buzzing about the casting of soap legend Erika Slezak as Monica’s sister. The anticipation is high for how she will embody the role and what secrets her arrival might unravel about Monica’s past.

Willow’s Manipulation

Meanwhile, Willow quietly stirs up trouble of her own. She pushes Chase to believe that Michael is the shooter in Drew’s case, planting seeds of suspicion where there may be none. The question is whether Chase will allow her manipulation to influence the investigation—and what this could mean for Michael’s already fragile place in Port Charles.

Joss and Vaughn’s Surprise Guest

Finally, Joss and Vaughn find themselves face-to-face with a visitor from the past—none other than Nathan, who may have returned from the dead. His shocking reappearance is set to send shockwaves through the community, reopening old wounds and raising dangerous new questions.

And what about Dex? With his fate still uncertain, fans are left wondering whether another miraculous survival could be in the works.

Final Thoughts

The upcoming two weeks on General Hospital promise everything fans love most about the show: emotional goodbyes, long-buried secrets, shocking resurrections, and tangled romances. From Monica’s tragic departure to the tantalizing possibility of Nathan’s return, the stakes have never been higher. As Port Charles grieves, reunites, and schemes, one truth remains certain: nothing stays buried for long in this town.