General Hospital Spoilers: September 22–26, 2025 — Monica’s Death Splinters Port Charles, Old Ghosts Return, and New Wars Ignite

The week of September 22–26, 2025 on General Hospital delivers an unrelenting storm of grief, betrayal, and revelations that threaten to fracture Port Charles forever. Monica Quartermaine’s death is not just a devastating personal loss — it’s the earthquake that sets off a chain reaction across the town. From the Quartermaine mansion to Anna Devane’s haunted psyche, from Molly Lansing’s unraveling world to Josslyn’s dangerous manipulation, every storyline this week feels like a match struck too close to gasoline.

Monica’s Death: The Matriarch’s Absence and the Quartermaine Implosion

From the moment news of Monica’s death spreads, Port Charles feels the tremor.

Monica had been more than the Quartermaine matriarch — she was the immovable center of a family defined by chaos. Without her, the carefully balanced web of grudges, reconciliations, and fragile alliances begins to snap. At the estate, every whispered conversation carries the weight of suspicion. Drew struggles to control Scout’s grief, Liz’s quiet announcement shakes the family to its core, and even before the funeral begins, the Quartermaines feel like a powder keg primed to detonate.

Lois Returns: Fire and Fury at the Funeral

Whispers travel fast: Lois Cerullo is back in town. Drawn not only by grief but also by duty and unfinished business, Lois storms into Port Charles in the only way Lois can — fiery, blunt, and ready to reignite conflicts others avoid.

At Monica’s funeral, Lois doesn’t just mourn. She challenges. She questions Drew’s rigid control, defends tradition, and voices opinions no one else dares to say aloud. Her presence turns mourning into confrontation, with tears colliding against raised voices in the church pews.

Monica’s Sister Arrives: Secrets Unburied

If Lois’ return stirs the pot, the arrival of Monica’s younger sister sets it boiling over.

Her existence had long been whispered about but never confronted. Her reappearance in the wake of Monica’s death reopens locked doors in the Quartermaine past — with the weight of grievances, potential claims to inheritance, and old secrets that could shatter what little unity remains.

Her quiet but cutting words pierce through the family gathering. Where Lois brings fire, Monica’s sister brings cold calculation, raising questions about Drew’s ability to raise Scout and even hinting at legal challenges that could reshape the Quartermaine future.

The funeral becomes a battlefield: every tear for Monica matched with accusations, old betrayals, and whispered threats. By the time Monica’s casket lowers into the ground, the Quartermaines are not united in grief — they are splintering into open war.

Nathan West Returns: A Miracle or Faison’s Legacy?

As if Port Charles wasn’t destabilized enough, a ghost from the past reappears: Nathan West.

His presence is impossible yet undeniable. Once buried and mourned, Nathan’s return shocks everyone, but especially Anna Devane. For Anna, his survival carries a stench she cannot ignore — the lingering shadow of Cesar Faison.

Could Nathan be free, or is he the embodiment of Faison’s manipulations? The timing is too precise, coinciding with whispers of Faison’s network resurfacing. Anna watches Nathan like a hawk, torn between wanting to believe in him and fearing he has been programmed, altered, or weaponized.

For Port Charles, Nathan’s return looks like a miracle. For Anna, it’s a curse — a sign that Faison’s story may not be over, but only entering a darker new chapter.

Molly and Cody: Custody Battles and the Basement Secret

While the Quartermaines wage their war, Molly tries to drown her pain in writing. But her alliance with Cody pulls her deeper into the battle for Scout’s custody. Their whispered strategies and late-night conversations form an unexpected bond — not romantic yet, but dangerously intimate.

Then comes the rumor that changes everything: Rick may still be alive — hidden in Alexis’s basement.

At first, Molly dismisses it as grotesque fantasy. But subtle clues, Alexis’s distracted behavior, and inconsistencies begin to align. The horrifying possibility grows: her mother may have been hiding Rick alive all this time.

If true, the revelation could not only destroy Alexis but also unravel Molly’s bond with Cody and throw Scout into even greater danger. For Molly, her attempt to escape through fiction collapses into obsession. She cannot shake the image of Rick pacing in the dark beneath her own home.

Brennan Targets Josslyn: A Love Undermined

Across town, Brennan sharpens his strategy and sets his sights on Josslyn.

He identifies her relationship with Vaughn as both her greatest strength and her deepest vulnerability. To isolate her, he offers a mission — painted as empowerment, cloaked in secrecy, designed to make her believe Vaughn is holding her back.

The mission flatters Josslyn’s pride, tempting her need to prove independence. But Brennan’s true aim is to wedge her away from Vaughn, turning allies into adversaries.

As Josslyn keeps secrets and walks deeper into Brennan’s game, Vaughn senses the distance but underestimates how far the manipulation has already gone. Their love becomes the battlefield Brennan wanted — a fragile foundation he intends to break apart.

Britt vs. Dalton: Secrets, Adjustments, and the Dare to Expose

Finally, another confrontation brews in the shadows: Britt versus Dalton.

For Britt, the lies have become unbearable. For Dalton, secrecy is power. As she presses him, Dalton doesn’t show fear — he dares her to expose him, knowing that the fallout would consume everyone, not just him.

Nathan’s return, Liesl’s odd behavior, and Anna’s suspicions are all threads in Dalton’s tangled web. He thrives on control through half-truths, framing manipulation as privilege. Britt realizes too late that exposing him may not weaken him, but instead unleash chaos that will burn through Port Charles.

Conclusion: A Town on the Edge of War

The week of September 22–26 is not about closure — it’s about escalation.

• Monica’s funeral leaves the Quartermaines more fractured than ever.

• Nathan’s return raises specters of Faison’s legacy.

• Molly’s fight for Scout pulls her into a nightmare of family secrets.

• Josslyn becomes Brennan’s latest pawn, risking her love with Vaughn.

• Britt faces Dalton, only to discover exposure may be exactly what he wants.

General Hospital is not mourning this week — it’s preparing for war. The death of Monica Quartermaine tore away Port Charles’ last thread of stability. What comes next will reshape not just families, but the very balance of power in the city.